DNA ligase-IN-2 - CAS 635681-64-0

DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.

DNA/RNA Synthesis, Antibacterial

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Microbiology/Virology

635617

C13H8FN3O3

273.219

O=C(N)C1=CC=2C(=O)C3=CC(F)=CC=C3OC2N=C1N

-20°C

Ice Packs

Small Compound