DNA-PK-IN-12 - CAS 2792146-91-7

DNA-PK-IN-12 (compound 31t), an orally active inhibitor of DNA-PK, demonstrates potent inhibition with an IC 50 of 0.1 nM. It effectively impedes Hct116 cell growth and colony formation, displaying an IC 50 of 33.28 μM, and exhibits antitumor activity in vivo [1].

DNA-PK

PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

2792146-91-7

C21H24N8O2

420.47

O=C1N(C=2C(N1C)=CN=C(NC=3C(C)=CC(=NC3)C4=CN(C)N=C4)N2)C5CCOCC5

-20°C

Ice Packs

Small Compound