DNA-PK-IN-8 - CAS 2823369-81-7

DNA-PK-IN-8 is a potent, selective, and orally active inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 0.8 nM, demonstrating synergistic antiproliferative effects across various cancer cell lines and significantly reducing HL-60 tumor growth when combined with Doxorubicin [1].

DNA-PK, Others

PI3K/Akt/mTOR signaling, Others, DNA Damage/DNA Repair

2823281

C19H22N8O2

394.43

CN1C=2C(N(CC1=O)C3CCOCC3)=NC(NC4=CN5C(C=C4C)=NC=N5)=NC2

-20°C

Ice Packs

Small Compound