DNJNAc - CAS 105265-96-1

DNJNAc, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of β-hexosaminidase (HEX) . HEX enzymes catalyze the hydrolysis of terminal non-reducing N-acetyl-β-D-glucosamine (GlcNAc) and N-acetyl-β-D-galactosamine (GalNAc) residues from glycoconjugates such as glycoproteins, gangliosides, and glycosaminoglycans. HEX secreted by chondrocytes into the extracellular space contributes to cartilage matrix degradation, and HEX activity is elevated in the synovial fluid of osteoarthritis patients.

Hexokinase, glycosidase

Metabolism

105168

0.9937

C8H16N2O4

204.22

N(C(C)=O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)NC1

-20°C

Ice Packs

Small Compound