DNL343 - CAS 2278265-85-1

DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) .

PERK

Apoptosis

2278179

>99.99%

C20H19ClF3N3O4

457.83

N(C(COC1=CC=C(Cl)C=C1)=O)C23CC(C2)(C3)C=4OC(=NN4)[C@@H]5C[C@H](OC(F)(F)F)C5

-20°C

Ice Packs

Small Compound