DOCK2-IN-1 - CAS 4590-86-7

DOCK2-IN-1, an analogue of CPYPP, effectively inhibits DOCK2 (IC50 = 19.1 μM) by reversibly binding to its DHR-2 domain, thereby hindering its catalytic function. This compound obstructs the activation of Rac in lymphocytes, triggered either by chemokine or antigen receptors. Consequently, DOCK2-IN-1 markedly reduces chemotactic responses and T cell activation [1].

Others

Others

4497

C16H11ClN2O2

298.72

O=C1N(NC(=O)C1=CC2=C(Cl)C=CC=C2)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound