Dopamine D3 receptor antagonist-3 - CAS 2894793-37-2

Dopamine D3 receptor antagonist-3 is a selective positive allosteric modulator-antagonist (PAM-antagonist) of the D3 dopamine receptor (D3R) that can cross the blood-brain barrier. It demonstrates antagonistic activity in D3R-mediated β-arrestin recruitment assays with an IC50 of 2.5 μM and Kb of 0.49 μM, and in D3R-mediated Go-BRET assays with an IC50 of 0.34 μM. Dopamine D3 receptor antagonist-3 is applicable for the study of neuropsychiatric disorders, including substance use disorders.

Dopamine Receptor

Neuroscience, GPCR/G Protein

2894754

C18H17ClF5N3O3S

485.86

O=C(C1=C(NC(=C1S(=O)(=O)NC2=CC=C(C(Cl)=C2)C(F)(F)F)C)C)N3CCC(F)(F)C3

-20°C

Ice Packs

Small Compound