Doxorubicin hydrochloride - CAS 25316-40-9

Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic and antitumor activity. It is an effective inhibitor of human DNA topoisomerase I and II, with IC50 values of 0.8 μM and 2.67 μM, respectively. In addition to inhibiting DNA topoisomerases, it can reduce the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase. Doxorubicin hydrochloride also induces apoptosis and autophagy. In animal studies, it is commonly used to induce models of acute renal failure, chronic kidney injury, and heart failure.

HBV, Apoptosis, HIV Protease, ADC Cytotoxin, Mitophagy, AMPK, Autophagy, Antibiotic, Antibacterial, Topoisomerase

Autophagy, Microbiology/Virology, Proteases/Proteasome, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Apoptosis, Antibody-drug Conjugate/ADC Related, DNA Damage/DNA Repair

25316-40-9

0.9957

C27H29NO11·HCl

579.99

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

-20°C

Ice Packs

Natural Product