DPP-21 - CAS 2924883-83-8

DPP-21 is an inhibitor of microtubule protein polymerization (IC50: 2.4 μM) . It exhibits antiproliferative activity against various cancer cell lines, with IC50 values of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23), and 9.37 nM (HepG2) . DPP-21 induces cell cycle arrest at the G2/M phase of mitosis and subsequently triggers apoptosis in tumor cells by decreasing Bcl-2 while increasing pro-apoptotic protein Bax levels.

Apoptosis

Apoptosis

2924792

C17H16N4S

308.4

N1=C(N=C(C=2SC=CC12)N(C=3C=CC4=C(C=CN4C)C3)C)C

-20°C

Ice Packs

Small Compound