DS-1558 - CAS 1202575-67-4

DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.

Others, GRK

Others, GPCR/G Protein

1202504

C21H21F3O4

394.38

C(F)(F)(F)C1=C2C([C@H](OC3=CC=C([C@H](CC(O)=O)OCC)C=C3)CC2)=CC=C1

-20°C

Ice Packs

Small Compound