DS79932728 - CAS 2757191-62-9

DS79932728 is an orally active inhibitor of G9a and GLP, with IC50 values of 12.6 nM and 75.7 nM, respectively. It induces the production of γ-globin, thereby increasing fetal hemoglobin (HbF) levels. In cynomolgus monkey models, DS79932728 enhances the proportion of F-reticulocytes (F-rets) and shows good oral absorption characteristics.

Glucagon Receptor, Histone Methyltransferase

Chromatin/Epigenetic, GPCR/G Protein

2757120

C19H25N3O

311.421

N=1C2=CC(=C(OC)C=C2C3(C1N)CCC3)C4=CCN(C)CCC4

-20°C

Ice Packs

Small Compound