DTS-108 - CAS 951792-83-9

DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor) . It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.

Topoisomerase

DNA Damage/DNA Repair

951700

C145H233N43O33S2

3170.8

C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)[C@@H]6CC[C@@H](CNC(=O)[C@@H]7CC[C@@H](CN8C(=O)C(SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC9=CN=CN9)C(N[C@H](C(N[C@H](C(=O)N%10[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)CC(O)=O)=O)CCSC)=O)CCCNC(=N)N)=O)[C@@H](C)O)=O)C(C)C)=O)CCCNC(=N)N)=O)CCC%10)CCCNC(=N)N)=O)C(C)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)[C@H](C)C)=O)N)CC8=O)CC7)CC6)=CC5

-20°C

Ice Packs

Small Compound