Dual Cathepsin L/JAK-IN-1 - CAS 2450279-41-9

DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI) .

P38 MAPK, Cysteine Protease, JAK, STAT, Interleukin

Chromatin/Epigenetic, Proteases/Proteasome, MAPK, Stem Cells, Tyrosine Kinase/Adaptors, Immunology/Inflammation, JAK/STAT signaling, Angiogenesis

2450229

C19H18ClN5

351.833

Cl.N1=CC=C(N=C1NC=2C=CC=C(N)C2)C3=CN(C=4C=CC=CC34)C

-20°C

Ice Packs

Small Compound