Duocarmycin A - CAS 118292-34-5

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

Apoptosis, Caspase, ADC Cytotoxin

Antibody-drug Conjugate/ADC Related, Proteases/Proteasome, Apoptosis

118253

C26H25N3O8

507.49

O=C1C=2[C@]34[C@](C3)(CN(C(=O)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC)C4=CC(=O)C2N[C@]1(C(OC)=O)C)[H]

-20°C

Ice Packs

Small Compound