Duocarmycin SA - CAS 130288-24-3

Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

DNA Alkylator/Crosslinker, Apoptosis, Necroptosis, ADC Cytotoxin, Antibiotic

DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related, Apoptosis, Microbiology/Virology

130261

C25H23N3O7

477.47

C(=O)(N1C=2[C@]3([C@](C3)(C1)[H])C4=C(NC(C(OC)=O)=C4)C(=O)C2)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC

-20°C

Ice Packs

Small Compound