Dyrk1A-IN-12 - CAS 2243701-11-1

Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A) . It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV) .

Enterovirus, DYRK, Virus Protease

Microbiology/Virology, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint

2243689

C22H16FN3O2S

405.445

O=C(NC1=CN=CC(=C1)C=2SC=C(C2)C=3C=NC=CC3)C4=CC(OC)=CC=C4F

-20°C

Ice Packs

Small Compound