Dyrk1A-IN-5 - CAS 1685235-41-9

Dyrk1A-IN-5 (compound 5j) is a highly potent and selective DYRK1A inhibitor with an IC50 of 6 nM, reducing the phosphorylation of Thr434 in SF3B1 dose-dependently (IC50 = 0.5 μM) and inhibiting tau phosphorylation at Thr212 (IC50 = 2.1 μM), making it valuable for Down syndrome research [1].

Others, DYRK

Tyrosine Kinase/Adaptors, Others, Cell Cycle/Checkpoint

1685185

C16H9IN2O2

388.16

C(O)(=O)C1=C2C(=C3C(=N1)C=CC=C3)NC=4C2=CC=CC4I

-20°C

Ice Packs

Small Compound