DZ2002 - CAS 33231-14-0

DZ2002, an orally active, reversible, and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), exhibits significant immunosuppressive activity. It effectively prevents experimental dermal fibrosis by reversing the profibrotic phenotype in multiple cell types, making it useful for studying autoimmune diseases like lupus syndrome and systemic sclerosis.

Antibacterial, Antibiotic, Akt, NF-κB, MEK, ERK, STAT, Others, PI3K

JAK/STAT signaling, Cytoskeletal Signaling, MAPK, NF-κB, PI3K/Akt/mTOR signaling, Others, Microbiology/Virology, Stem Cells

33217

0.9991

C10H13N5O3

251.24

COC(=O)C(O)CCn1cnc2c(N)ncnc12

-20°C

Ice Packs

Small Compound