(E) -2,6-Di-tertbutyl-4 (4- (diethylamino) styryl) pyrylium TFA - CAS 2811663-45-1

(E) -2,6-Di-tert-butyl-4- (4- (diethylamino) styryl) pyrylium TFA (Compound 4a) functions as a Gram-negative outer membrane permeabilizer by targeting Met47 in LptA to disrupt LptA/LptC interactions, exhibiting synergistic antibacterial activity. This compound, when in the form of (trifluoromethanesulfonate), enhances the efficacy of pol B against both wild-type and multi-drug resistant A. baumannii and E. coli strains. Additionally, (E) -2,6-Di-tert-butyl-4- (4- (diethylamino) styryl) pyrylium (trifluoromethanesulfonate) serves as an adjuvant for antibiotics combating multi-drug resistant Gram-negative bacteria.

Antibacterial

Microbiology/Virology

2811617

C26H36F3NO4S

515.629

C(S(=O)(=O)[O-])(F)(F)F.C(=C/C1=CC=C(N(CC)CC)C=C1)\C=2C=C(C(C)(C)C)[O+]=C(C(C)(C)C)C2

-20°C

Ice Packs

Small Compound