(E) -2-Hexadecenal - CAS 22644-96-8

Sphingosine-1-phosphate (S1P), a bioactive lipid crucial in numerous signaling pathways, undergoes irreversible degradation by membrane-bound S1P lyase, producing (E) -2-Hexadecenal, a derivative of sphingolipid breakdown. This compound can be oxidized to (2E) -hexadecenoic acid by long-chain fatty aldehyde dehydrogenase before being activated through linkage to coenzyme A. Notably, (E) -2-Hexadecenal induces cytoskeletal reorganization, leading to cell rounding, detachment, activation of JNK pathway targets, and ultimate apoptosis in a variety of cell types. Furthermore, it readily forms aldehyde-derived DNA adducts through reactions with deoxyguanosine and DNA.

Microtubule Associated, Others, JNK, MLK, Apoptosis

MAPK, Apoptosis, Cytoskeletal Signaling, Others

22644-96-8

C16H30O

238.415

CCCCCCCCCCCCC\C=C\C=O

-20°C

Ice Packs

Small Compound