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Molfinity

E 2012 - CAS 870843-42-8

E 2012 - CAS 870843-42-8

MF-0018010-01

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Product Details

  • Bioactivity

    E2012 is a γ-secretase modulator (GSM) . E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.

  • Target

    Gamma-secretase

  • Related Pathways

    Stem Cells, Proteases/Proteasome, Neuroscience

  • CAS Number

    870793

  • Purity

    0.9983

  • Molecular Formula

    C25H26FN3O2

  • Molecular Weight

    419.49

  • SMILES

    COc1cc(\C=C2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound