(E) -5- (2-Bromovinyl) uracil - CAS 69304-49-0

(E) -5- (2-Bromovinyl) uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E) -5- (2-bromovinyl) -2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.

Others, DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others

69304-49-0

C6H5BrN2O2

217.02

C(=C/Br)\C=1C(=O)NC(=O)NC1

-20°C

Ice Packs

Small Compound