(E/Z) -GSK5182 - CAS 2699724-40-6

(E/Z) -GSK5182 (GSK5182 (Z/E) ) is a racemic mixture comprising (E) -GSK5182 and (Z) -GSK5182 isomers. It acts as a highly selective and orally active inverse agonist for the estrogen-related receptor γ (ERRγ), demonstrating potency with an IC50 of 79 nM. Additionally, GSK5182 is known to induce the generation of reactive oxygen species (ROS) in hepatocellular carcinoma.

Reactive Oxygen Species, Estrogen/progestogen Receptor, Estrogen Receptor/ERR, ROS

Metabolism, Immunology/Inflammation, NF-κB, Endocrinology/Hormones

2699678

0.9883

C27H31NO3

417.54

CN(C)CCOC1=CC=C(C=C1)C(=C(CCCO)C1=CC=CC=C1)C1=CC=C(O)C=C1

-20°C

Ice Packs

Small Compound