(E/Z) -Rigosertib sodium - CAS 1225497-78-8

ON-01910 is a non-ATP-competitive PLK1 inhibitor (IC50 of 9 nM, in a cell-free assay) . It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.

PLK

Cell Cycle/Checkpoint

1225411

0.9982

C21H24NNaO8S

473.47

[Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1

-20°C

Ice Packs

Inhibitors & Agonists