E0924G - CAS 2909474-29-7

E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.

PPAR

DNA Damage/DNA Repair, Metabolism

2909438

C12H12N2O3

232.24

O=C(NC1=NC=CC(OC)=C1)C=2OC(=CC2)C

-20°C

Ice Packs

Small Compound