E6201 - CAS 603987-35-5

E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM) . E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].

FLT, MEK, Others

MAPK, Others, Tyrosine Kinase/Adaptors, Angiogenesis

603987-35-5

C21H27NO6

389.44

OC1=C2C(=CC(NCC)=C1)/C=C/C[C@H](O)[C@H](O)C(=O)\C=C\[C@@H](C)[C@H](C)OC2=O

-20°C

Ice Packs

Small Compound