E6446 - CAS 1219925-73-1

E6446 inhibits Toll-like receptor (TLR) 7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG) -containing DNA, which stimulates TLR9.

TLR, Stearoyl-CoA Desaturase (SCD)

Immunology/Inflammation, Metabolism

1219851

0.9999

C27H35N3O3

449.59

O(CCCN1CCCC1)C=2C=C3C(N=C(O3)C4=CC=C(OCCCN5CCCC5)C=C4)=CC2

-20°C

Ice Packs

Small Compound