EBI-907 - CAS 1581764-31-9

EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM) . EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E) -dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases including BRK, FGFR1, c-Kit, and PDGFRb.

Raf, Others

MAPK, Others

1581724

C23H21ClF2N4O3S

506.95

O(C)C1=CC2=C3C(=NN=C3NC=C2C=C1C4=C(Cl)C(NS(CCCF)(=O)=O)=CC=C4F)C5CC5

-20°C

Ice Packs

Small Compound