Ebselen - CAS 60940-34-3

Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS) . In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

HIV Protease, Phosphatase, Calcium Channel, COX, Virus Protease

Proteases/Proteasome, Immunology/Inflammation, Neuroscience, Metabolism, Membrane transporter/Ion channel, Microbiology/Virology

60903

0.9994

C13H9NOSe

274.18

O=C1N([Se]C=2C1=CC=CC2)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound