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EC 144 - CAS 911397-80-3
EC 144 - CAS 911397-80-3
SKU:MF-0138763-01
Regular price
$1,787.45 USD
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$1,787.45 USD
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Product Details
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Bioactivity
EC 144, a second-generation selective inhibitor of Hsp90 (heat shock protein 90), inhibits tumor growth with an IC50= 1.1 nM for Hsp90α and an EC50 = 14 nM for degradation of Her-2 in MCF-7 cells.
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Target
HSP
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Related Pathways
Metabolism, Cytoskeletal Signaling
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CAS Number
911314
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Molecular Formula
C21H24ClN5O2
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Molecular Weight
413.9
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SMILES
ClC1=NC(=NC2=C1C(C#CCC(O)(C)C)=CN2CC3=NC=C(C(OC)=C3C)C)N
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Storage Temperature
-20°C
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Shipping Conditions
Ice Packs
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Category
Small Compound