ED11 - CAS 1593480-56-8

ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. It competes with Htt for the caspase-6 active site, thereby reducing Htt cleavage. ED11 is capable of crossing the blood-brain barrier (BBB) and holds potential for researching Huntington's disease (HD) .

Caspase

Apoptosis, Proteases/Proteasome

1593480-56-8

C116H205N47O37

2850.16

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(CN)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC1)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)=O)CC(O)=O)=O)CC(C)C)=O)C(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CO)=O)CO)=O)CCC(N)=O)=O)CCC2

-20°C

Ice Packs

Peptide