Edicotinib - CAS 1142363-52-7

Edicotinib (JNJ-527) is a blood-brain-penetrating, orally active, selective CSF-1R inhibitor (IC50 value is 3.2 nM), with less inhibitory effects on KIT (IC50 value is 20 nM) and FLT3 (IC50 value is 190 nM) . Edicotinib (JNJ-527) can block microglial proliferation and attenuate neurodegeneration, and can be used to study Alzheimer's disease and rheumatoid arthritis.

C-Kit, CSF-1R, c-Fms, FLT

Tyrosine Kinase/Adaptors, Angiogenesis

1142304

0.9972

C27H35N5O2

461.6

CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1

-20°C

Ice Packs

Small Compound