Efonidipine hydrochloride - CAS 111011-53-1

Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N (6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP) -induced StAR mRNA and DHEA-S production in NCI-H295R adrenocortical carcinoma cells, actions reflective of adrenocorticotropic hormone. Efonidipine uniquely inhibits calcium channels by merging tonic and use-dependent blocking methods. Its inhibitory concentrations (IC50) for I (Ca (T) ) and I (Ca (L) ) are 0.35 micromol/l and 1.8 nmol/l, respectively. Clinically, efonidipine administered to hypertensive patients undergoing chronic hemodialysis (20-60 mg, twice daily) demonstrated comparable blood pressure control to amlodipine (2.5-7.5 mg, once daily) over a 12-week period without significantly altering pulse rate. Furthermore, efonidipine significantly improved left ventricular ejection fraction in heart failure models without affecting blood pressure, in addition to lowering the heart rate by about 10%.

Calcium Channel, Others

Metabolism, Others, Membrane transporter/Ion channel

110957

C34H39ClN3O7P

668.12

Cl.O=C(OCCN(C=1C=CC=CC1)CC=2C=CC=CC2)C3=C(NC(=C(C3C=4C=CC=C(C4)N(=O)=O)P5(=O)OCC(C)(C)CO5)C)C

-20°C

Ice Packs

Small Compound