EGFR/AURKB-IN-1 - CAS 3008543-34-5

EGFR/AURKB-IN-1 (compound 7) serves as a dual inhibitor targeting EGFR/AURKB, effectively inhibiting the phosphorylations of L858R EGFR and AURKB with IC50 values of 0.07 and 1.1, respectively. The compound engages with the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB. This binding action suppresses tumor cell growth, division, and metastasis, making it a valuable agent for cancer research [1].

EGFR, Aurora Kinase

Angiogenesis, JAK/STAT signaling, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic

3008543-34-5

C23H20N6O

396.44

N(C1=C2C(NC(=C2)C=3N(C)N=CC3)=NC=N1)C4=CC=C(OCC5=CC=CC=C5)C=C4

-20°C

Ice Packs

Small Compound