EGFR/c-Met-IN-1 - CAS 3020728-68-8

EGFR/c-Met-IN-1 (compound TS-41) is a dual inhibitor targeting EGFR and c-Met, with IC50 values of 68.1 nM for EGFRL858R and 0.26 nM for c-Met. EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, and reduces phosphorylation of EGFR, c-Met, and downstream AKT. This compound effectively inhibits tumor growth both in vitro and in vivo.

C-Met/HGFR, EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

3020652

C30H25FN6O5

568.56

O=C(C=C)NC1=CC=2C(=NC=NC2C=C1OC)OC3=CC=C(C=C3F)NC(=O)C=4C(=O)N(C=5C=CC=CC5)N(C4C)C

-20°C

Ice Packs

Small Compound