EGFR/HER2-IN-11 - CAS 1346176-20-2

EGFR/HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].

EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

1346176-20-2

C23H21ClF3N5O2

491.89

N(C1=C2C(C=CN2CCNCCO)=NC=N1)C3=CC(Cl)=C(OC4=CC(C(F)(F)F)=CC=C4)C=C3

-20°C

Ice Packs

Small Compound