EGFR/HER2-IN-12 - CAS 2237230-21-4

EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].

EGFR

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

2237230-21-4

C25H17ClN4O3S

488.95

N(C1=C2C(SC(=C2)C3=CC=C(N(=O)=O)C=C3)=NC=N1)C4=CC(Cl)=C(OC5=CC(C)=CC=C5)C=C4

-20°C

Ice Packs

Small Compound