EGFR-IN-1 - CAS 1625677-63-5

EGFR-IN-1, an orally active and irreversible selective inhibitor targeting L858R/T790M mutant EGFR, exhibits strong antiproliferative and antitumor activity, particularly against H1975 cells and first line mutant HCC827 cells. This compound potently inhibits Gefitinib-resistant EGFR L858R/T790M mutations with a 100-fold selectivity over the wild-type EGFR.

EGFR

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

1625677-63-5

C28H30N6O4

514.58

O=C1N(C=2C(=CN=C(NC3=C(OC)C=C(OCCN(C)C)C=C3)N2)C(C)=C1)C4=CC(NC(C=C)=O)=CC=C4

-20°C

Ice Packs

Small Compound