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EGFR-IN-1 hydrochloride - CAS 2227455-78-7

EGFR-IN-1 hydrochloride - CAS 2227455-78-7

MF-0014128-01

$54.10 USD
$54.10 USD
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Product Details

  • Bioactivity

    EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR. It exhibits potent antitumor and antiproliferative activity in H1975 cells and mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.

  • Target

    EGFR

  • Related Pathways

    Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

  • CAS Number

    2227370

  • Purity

    0.998

  • Molecular Formula

    C28H31ClN6O4

  • Molecular Weight

    551.04

  • SMILES

    Cl.O=C(C=C)NC1=CC=CC(=C1)N2C(=O)C=C(C=3C=NC(=NC32)NC4=CC=C(OCCN(C)C)C=C4OC)C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound