EGFR-IN-11 - CAS 2463200-44-2

EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.

Apoptosis, EGFR

Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2463154

0.9993

C29H35N9O2S

573.71

CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1

-20°C

Ice Packs

Small Compound