EGFR-IN-117 - CAS 3035639-05-2

EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.

EGFR, Apoptosis

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Apoptosis

3035639-05-2

C25H30BrN7O2S

572.52

O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)N4CCN(C)CCC4)C5CC5

-20°C

Ice Packs

Small Compound