EGFR-IN-125 - CAS 2472802-77-8

EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of <0.3 nM for EGFR (d746-750/T790M/C797S), 0.52 nM for EGFR (L858R/T790M/C797S), 0.5 nM for EGFR (d746-750/C797S), 0.69 nM for EGFR (L858R/C797S), and 0.92 nM for EGFR (wild type) .

EGFR

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling

2472717

C30H26N8O

514.58

O=C(NC12CCC(N3C(C#C)=C(C=4C=NC=5C=CC=CC5C4)C=6C(=NC=NC63)N)(CC1)C2)C7=NC=C(N=C7)C

-20°C

Ice Packs

Small Compound