EGFR-IN-133 - CAS 2809982-26-9

EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.

EGFR, Antifungal

JAK/STAT signaling, Angiogenesis, Microbiology/Virology, Tyrosine Kinase/Adaptors

2809947

C27H29F2N7O3

537.56

FC1=C2N3C(NC2=CC(N[C@@H]4CCOC4)=C1)=NC(=O)C=5C=C(C6=C(OCCC[C@@H](C)C3)N(C)N=C6)N=C(F)C5

-20°C

Ice Packs

Small Compound