EGFR-IN-139 - CAS 1574321-31-5

EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S) . It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC) .

EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

1574285

C27H25ClN2O4

476.951

Cl.O=C(C=1OC2=C(N=CC(=C2C1)CN3CC=4C=CC=CC4CC3)C)C5=CC=C6OCCOC6=C5

-20°C

Ice Packs

Small Compound