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EGFR-IN-141 - CAS 3054263-27-0

EGFR-IN-141 - CAS 3054263-27-0

MF-0113420-01

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Product Details

  • Bioactivity

    EGFR-IN-141 (Compound 8I) functions as an EGFR inhibitor with an IC50 of 2.67 nM. It exhibits cytotoxicity in A549 cancer cells with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization and shows potential antitumor activity.

  • Target

    Apoptosis, EGFR

  • Related Pathways

    JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis

  • CAS Number

    3054236

  • Molecular Formula

    C20H15FN8O2S2

  • Molecular Weight

    482.514

  • SMILES

    O=C1C=2C=CC=CC2N=CN1CC3=NN=C(SCC(=O)NC4=NC=5C=CC(F)=CC5S4)N3N

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound