EGFR-IN-150 - CAS 3037323-16-0

EGFR-IN-150 is an EGFR inhibitor that effectively inhibits the phosphorylation of mutant epidermal growth factor receptor (EGFR) and its downstream AKT signaling pathway, exerting antitumor effects and inducing HMOX1 expression to trigger ferroptosis. This compound exhibits an IC50 of 0.386 μM against the non-small cell lung cancer (NSCLC) cell line H1975 and significantly suppresses the colony formation and migration abilities of H1975 and A549 cells, while also inducing apoptosis. Additionally, EGFR-IN-150 prominently reduces tumor growth in H1975 tumor-bearing mouse CDX models. It holds promise for research related to non-small cell lung cancer.

EGFR, Apoptosis

JAK/STAT signaling, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors

3037307

C29H23ClN6O2

522.985

C(=C\1/C=2C(NC1=O)=CC=C(NC=3N=C(NC4=C(NC(C=C)=O)C=CC=C4)C(Cl)=CN3)C2)\C5=C(C)C=CC=C5

-20°C

Ice Packs

Small Compound