EGFR-IN-159 - CAS 2055746-08-0

EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.

EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2055746-08-0

C21H23N3O5

397.424

O=C1NC(=C(C(=O)NC=2C=CC=CC2OC)C(N1)C3=CC=C(O)C(OCC)=C3)C

-20°C

Ice Packs

Small Compound