EGFR-IN-161 - CAS 3031099-34-7

EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.

Apoptosis, EGFR

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Apoptosis

3031058

C33H36Cl2N8O2

647.597

C(CCO)N1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)C)C(/N=C/C=5C(Cl)=C(Cl)N=CC5)=C4)=NC=C3

-20°C

Ice Packs

Small Compound