EGFR-IN-2 - CAS 1643497-70-4

EGFR-IN-2 is a non-covalent, orally available and mutation-selective EGFR inhibitor for the treatment of non-small cell lung cancer (NSCLC), with high selectivity for resistant single and double mutant T790M with IC50 = 27 nm to 33 nM, and low inhibitory activity for wild-type H292 (IC50 = 218 nM) .

EGFR

JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

1643423

0.9979

C26H33N9O3S

551.66

[C@@H](CC)(C)N1N=C(C=2C1=CC(NC3=NC(=NC=C3)C4=CN(S(=O)(=O)C5CC5)N=C4)=NC2)N6CC(C(C)(C)O)C6

-20°C

Ice Packs

Small Compound