EGFR-IN-52 - CAS 454436-75-0

EGFR-IN-52 (Compound 4) is a highly effective inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 0.358, 86.02, and 432.67 μM against EGFR, EGFR L858R-TK, and EGFR T790M-TK, respectively. Additionally, it demonstrates potent cytotoxic effects on cancer cell lines and triggers apoptosis [1].

EGFR, Apoptosis, Others

Others, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis

454361

C19H18N4O3S

382.44

CN1N(C(=O)C(NC(=S)NC2=CC3=C(OCO3)C=C2)=C1C)C1=CC=CC=C1

-20°C

Ice Packs

Small Compound